The objective of the present study is to develop colon targeted drug delivery system by using combination of Xanthan gum and Guar gum in different proportions by employing Theophylline as model drug. Matrix tablets containing various excipients and Xanthan gum were prepared by wet granulation technique using different concentrations. All the prepared tablets were evaluated for Hardness, Weight variation, Drug uniformity, Friability and In-vitro drug release study. The final product is expected to release its contents in colonic region. The results of in-vitro study indicated that matrix tablets containing combination of Xanthan gum and Guar gum (20:10) and PVP as binder are most suitable to deliver the drug specifically in colonic region. The final formulation F6 which contains Xanthan gum and Guar gum in the proportion of 20:10 was suitable for achieving colon specific drug delivery for the treatment of nocturnal symptoms of asthma.
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